Structural and functional evaluation of C. elegans filamins FLN-1 and FLN-2.
Filamins are long, flexible, multi-domain proteins composed of an N-terminal actin-binding domain (ABD) followed by multiple immunoglobulin-like repeats (IgFLN).They function to organize and maintain the actin cytoskeleton, to provide scaffolds for signaling components, and to act as mechanical force sensors.In this study, we used transcript Disinf